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Tibetan adaptation to high altitude occurred in less than 3,000 years

July 1

Tibetans have mutations in numerous genes related to how the body uses oxygen. A comparison of the genomes of 50 Tibetans and 40 Han Chinese shows that ethnic Tibetans split off from the Han less than 3,000 years ago and since then rapidly evolved a unique ability to thrive at high altitudes and low oxygen levels.

The genome-wide comparison, performed by evolutionary biologists at the University of California, Berkeley, uncovered more than 30 genes with DNA mutations that have become more prevalent in Tibetans than Han Chinese, nearly half of which are related to how the body uses oxygen. One mutation in particular spread from fewer than 10 percent of the Han Chinese to nearly 90 percent of all Tibetans.

“This is the fastest genetic change ever observed in humans,” said Rasmus Nielsen, UC Berkeley professor of integrative biology, who led the statistical analysis. “For such a very strong change, a lot of people would have had to die simply due to the fact that they had the wrong version of a gene.”

via Tibetan adaptation to high altitude occurred in less than 3,000 years.

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